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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 61-66 doi: 10.1007/s11684-009-0007-8

Abstract: The aim of this study was to explore the regulatory mechanism of retinoic acid (RA) on the TBX1 geneThe expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measuredWhen treated with 3×10 mol/L RA, we observed that the expression of Shh mRNA and protein in neonatalMeanwhile, we could detect that the expression of Fgf8 mRNA and protein were up-regulated by 2.50 timesAt the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1

Keywords： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 66-72 doi: 10.15302/J-FASE-2015047

Abstract: The immune mapped protein 1 (NcIMP1) was identified as a membrane protein, and a previous study indicatedthat NcIMP1 could be a promising vaccine candidate against neosporosis.In this study, the immune response and protection efficacy of NcIMP1 were evaluated.responses against recombinant NcIMP1, with a mixed IgG1/IgG2a response and a predominance of IgG2a productionThe parasite burden was significantly reduced in the pcDNA-IMP1-vaccinated mice.

Keywords： Neospora caninum     immune mapped protein 1 (IMP1)     vaccine candidate     BALB/c mice    

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PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Frontiers of Agricultural Science and Engineering   Pages 262-279 doi: 10.15302/J-FASE-2021383

Abstract: D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plantsHere, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and highprotein production at both transcriptional and translational levels.Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition.

Keywords： D1 turnover     photoinhibition     photoprotection     photosynthesis     tomato     xanthophyll cycle    

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PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (SOLANUM LYCOPERSICUM) UNDER

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract:

D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plantsHere, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and highprotein production at both transcriptional and translational levels.Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition.

Keywords： D1 turnover / photoinhibition / photoprotection / photosynthesis / tomato / xanthophyll cycle    

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Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 575-589 doi: 10.1007/s11684-019-0693-9

Abstract: The PG form of dentin matrix protein 1 (DMP1-PG) is involved in maintaining the health of articular cartilageOur previous data have shown that DMP1-PG is richly expressed in the cartilaginous calluses of fractureHowever, the possible significant role of DMP1-PG in chondrogenesis and fracture healing is unknown.by using a glycosylation site mutant DMP1 mouse (S89G-DMP1 mouse).Given the deficiency of DMP1-PG, the impaired IL-6/JAK/STAT signaling pathway was observed to affect

Keywords： fracture     extracellular matrix     dentin matrix protein 1     proteoglycan     cartilage    

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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: Proteinase-activated receptors (PARs) are a novel subclass of seven transmembrane-spanning, G protein-coupledHowever, little is known about the function of PAR-1, 2 in acute graft host disease (GVHD).In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelPAR-1, 2 protein expression was in accordance with the mRNA expression, as shown by Western blot.PAR-1 and PAR-2 may play an important role in the pathogenesis of acute GVHD.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 458-475 doi: 10.1007/s11684-022-0968-4

Abstract: In particular, mouse Ly-6A/Sca-1 is a widely used marker for various stem cells; however, its human orthologWe cloned the full-length LY6A cDNA, whose encoded protein sequence, domain architecture, andexon‒intron structures are all well conserved with mouse Ly-6A/Sca-1.Ectopic expression of the LY6A protein in cells demonstrates that it acts the same as mouse Ly-6A/Sca-1 in their processing and glycosylphosphatidylinositol anchoring to the cell membrane.

Keywords： LU domain-containing protein family     novel human gene     LY6A     pituitary tumor     biomarker     nonsynonymousSNP     GPI-anchored protein    

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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract:

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkheadbox protein A2 (FOXA2) are key transcription factors that regulate a complex gene network in the liverOur in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studiedshort palindromic repeats/dead Cas9 (CRISPR/dCas9) molecular tool for the downregulation of the HNF1A–FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.

Keywords： interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9)     Epigenetics     Hepatocyte nuclear factor 1alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract: In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressedKaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictorOverexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdownof PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Construction of a CaHPO4-PGUS1 hybrid nanoflower through protein-inorganic self-assembly, and its application

Tian Jiang, Yuhui Hou, Tengjiang Zhang, Xudong Feng, Chun Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 3,   Pages 554-562 doi: 10.1007/s11705-019-1834-z

Abstract: Using site-directed mutagenesis, we previously obtained a variant of -glucuronidase from Li-3 (PGUS1)In this study, a facile method was established to prepare a CaHPO -PGUS1 hybrid nanoflower for enzymeimmobilization, based on protein-inorganic hybrid self-assembly.Under optimal conditions, 1.2 mg of a CaHPO -PGUS1 hybrid nanoflower precipitate with 71.2% immobilizationand scanning electron microscope results showed that the enzyme was encapsulated in the CaHPO -PGUS1

Keywords： β-glucuronidase     enzyme-inorganic hybrid nanoflower     biotransformation     glycyrrhizin     glycyrrtinic acid 3-O-mono-β-D-glucuronide    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: To investigate the regulation of tumor suppressor XAF1 gene expression in digestive system cancers, westudied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell linestranscription activity was determined by dual-luciferase report assay, and enhanced green fluorescent proteinExpression of green fluorescent protein (GFP) under the control of XAF1 promoter in the three digestivecell lines may be due to loss of transcription activity of XAF1 promoter.

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: metabolism, survival, and immune response by forming two important complexes, namely, mTOR complex 1(mTORC1) and complex 2 (mTORC2). mTOR signaling is often dysregulated in cancers and has been consideredmade to develop efficacious mTOR inhibitors, particularly mTOR kinase inhibitors, which suppress mTORC1findings on the essential role of GSK3 in mediating cancer cell response to mTOR inhibitors and mTORC1inhibition-induced upregulation of PD-L1 in cancer cells may provide some explanations.

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 362-372 doi: 10.15302/J-FASE-2018206

Abstract: Proteome analysis, histological observation and PEPT1 quantification of the jejunum were performed.The results indicated that rats fed with chicken proteins had higher PEPT1 mRNA and protein levels (protein can regulate oligopeptidetransport mainly by upregulating PEPT1 protein expression and reducing dipeptidyl-peptidase activityAlthough intake of beef and fish proteins had no significant effect on PEPT1 expression, they altered

Keywords： Hippo signaling pathway     meat protein     PEPT1     proteome analysis     rat jejunum    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Title Author Date Type Operation

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Journal Article

immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Journal Article

PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Journal Article

PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (SOLANUM LYCOPERSICUM) UNDER

Journal Article

Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

Construction of a CaHPO4-PGUS1 hybrid nanoflower through protein-inorganic self-assembly, and its application

Tian Jiang, Yuhui Hou, Tengjiang Zhang, Xudong Feng, Chun Li

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article